distribution of ace insertion/deletion (i/d) polymorphism in iranian populations

angiotensin converting enzyme (ace; omim: 106180) has an important role in the conversion of angiotensin i to angiotensin ii and degradation of bradykinin. genetic polymorphism i/d (rs4646994) in the gene encoding ace has been well defined. to get more insight into the genetic structure of iranian populations, the distribution of the ace i/d polymorphism among iranians was compared with each other and with other populations. prevalence of the d allele was 0.5886 (95% ci: 0.5725-0.6047) in iran. there was significant difference between iranian populations (chi2=27.7, df=6, p2=10.15, df=5, p=0.071). the d allele showed high frequency in iran which is similar to caucasians.